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Curriculum | Title: Organic Chemistry I (Code-09040103) | First Sem | Master of Chemistry

Curriculum

Title: Organic Chemistry I (Code-09040103)

S.no. Topic Learning Objectives Teaching guidelines Methodology Time
1 Unit-1                                                                           Delocalized chemical bonding –conjugation, cross conjugation, resonance, hyperconjugation , tautomerism, students should be able to understand the concept of aromaticity, HMO, PMO approach and how it can be utilized further in organic chemistry. Along with the structure and poperties of inclusive compounds To Cover all the phenomenon of delocalization, aromaticity, HMO, PMO Approach, Their application to different system, addition compounds as given, their structure 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 11
Aromaticity in benzenoid and non-benzenoid compounds, alternant and non-alternant hydrocarbons, Huckel’s rule,
energy level of p-molecular  orbitals, annulenes, antiaromaticity, homo-aromaticity, PMO approach,
Bonds weaker than covalent, addition compounds, crown ether complexes and cryptands, inclusion compounds, cyclodextrins, catenanes and rotaxanes
2 Unit-2                                                                              Chirality, elements of symmetry, molecules with more than one chiral centre, diastereomerism. Students should understand the stereochemistry , geometrical, optical isomerism their method of resolution and properties To cover the elemets of symmetry, optical activity with and without chilral centre, their relative and absolute configuration, R-S, E-Z, erthro, threo nomemclature, Assymmentric synthesis and conformational analysis of compounds 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 12
Determination of relative and absolute configuration (octant rule excluded) with special reference to lactic acid, aniline & mandelic acid.
Methods of resolution, optical purity, prochirality, enantiotopic and diastereotopic atoms, groups and faces, asymmetric synthesis, cram’s rule and its modifications, prelog’s rule,
conformational analysis of cycloalkanes (upto six membered rings), decalins, conformations of sugars, optical activity in absence of chiral carbon (biphenyls, allenes and spiranes),
chirality due to helical shape, geometrical isomerism in alkenes and oximes, methods of determining the configuration.
3 Unit- 3                                                                                    Types of mechanisms, types of reactions, thermodynamic and kinetic requirements, kinetic and thermodynamic control, student should be able to correrate the and identify the mechanism, their reaction intermediate, what is Hammett & taft equation and how it can be applied To coverkinetic and thermodynamic stability, P-E diagram, HSAB principle, Reaction Intermediates and Effect of structure on the reactvity. 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 9
Hammond’s postulate, Curtin-Hammett principle.  Potential energy diagrams, transition states and intermediates, methods of determining mechanisms, isotope effects.
Hard and soft acids and bases.  Generation, structure, stability and reactivity of carbocations, carbanions, free radicals, carbenes and nitrenes.
 Effect of structure on reactivity.  The Hammett equation and linear free energy relationship, substituent and reaction constants.  Taft equation.
4  Unit – 4                                                                                   Type of naturally occurring sugar, Deoxy sugars, amino sugars and branch chain sugars Students should know about the carbhydrates and dyes To cover structural determination of giev sugar and dyes 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 8
 general methods of determination of structure and ring size with particular reference to maltose, lactose, sucrose, starch and cellulose.
Various classes of dyes, synthetic dyes including heterocyclic dyes, interaction between dyes and fibers, Structure elucidation of indigo and Alizarin.