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Curriculum | Title: Organic Chemistry II (Code 09040203) | Second Sem | Master of Chemistry

Curriculum

Title: Organic Chemistry II (Code 09040203)

S.no. Topic Learning Objectives Teaching guidelines Methodology Time
1  Unit-1                                                                                            The SN2, SN1, mixed SN1 and SN2,  SNi , SN1’, SN2’ SNI’ and SET mechanisms.  The neighbouring group mechanisms, neighbouring group participation by p and s bonds, anchimeric assistance. Students should be able to understand different type of mechanism of nucleophillic substitution reactions, stereochemistry of product and effect of neighbouring group, environment etc To cover all different type of nucleophillic substiution, NGP, different type of carbocation, ambident nucleophile, PTC 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 12
Classical and non-classical carbocations, phenonium ions, common  carbocation rearrangements.
Application of NMR spectroscopy in the detection of carbocations.
Reactivity- effects of substrate structure, attacking nucleophile, leaving group and reaction medium. Ambident nucleophile, regioselectivity.  Phase transfer catalysis.
2  Unit -2                                                                              Bimolecular mechanisms – SE2 and SEi.  The SE1 mechanism, Electrophilic substitution accompained by double bond shifts.  Effect of substrates, leaving group and the solvent polarity on the reactivity. Students should be able to understand different type of mechanism of electrophillic  substitution reactions, stereochemistry of product and ortho, para effect, and diiferent type of recations. To cover reactions of aromatics compounds, i.e electrophillic substitution reaction, benzyne mechanism and different type of name reaction 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 10
The arenium ion, mechanism, orientation and reactivity, energy profile diagrams.
The ortho/para ratio, ipso attack, orientation in other ring systems.  Quantitative treatment of reactivity in substrates and electrophiles.  Diazonium coupling, Vilsmeir reaction, Gattermann-Koch reaction.
The ArSN1, ArSN2, Benzyne and SRN1 mechanisms. Reactivity –
effect of substrate structure, leaving group and attacking nucleophile.  The von Richter, Sommelet-Hauser, and Smiles rearrangements.
3  Unit- 3                                                                                           The E2, E1 and E1cB mechanisms . Orientation of the  double bond .  Reactivity –effects of substrate structures, attacking base, the leaving group and the medium.  Mechanism and orientation in pyrolytic elimination. Student should know about the elemination reaction, regioand chemiselectivity, and different type of elemination and addition reactions To cover mechanism of elemination and addition reaction and diiferent type of addtion and elemination reaction given by compounds 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 12
Mechanistic and stereochemical aspects of addition reactions involving electrophiles, nucleophiles and free radicals, regio – and chemoselectivity, orientation and reactivity.  Addition to cyclopropane ring
Hydrogenation of double and triple bonds, hydrogenation of aromatic rings.  Hydroboration.  Michael reaction.  Sharpless asymmetric epoxidation.
4 Mechanism of metal hydride reduction of saturated and unsaturated carbonyl compounds,  acids, esters and nitriles.  Addition of Grignard reagents, organozinc and organolithium reagents to carbonyl and unsaturated carbonyl compounds. Student should be able understand all different kind of mechanism given by different compounds To cover metal hydride reduction of carbonyl compounds, mechanistic approach of all name raections given 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 7
Wittig reaction.  Mechanism of condensation reactions involving enolates – Aldol, Knoevenagel, Claisen, Mannich, Benzoin, Perkin and Stobbe reactions. Hydrolysis of esters and amides, ammonolysis of esters.
Admission 2017