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Curriculum | Title: Organic Special -I (Code-09040313) | Third Sem | Master of Chemistry

Curriculum

Title: Organic Special -I  (Code-09040313)

S.no. Topic Learning Objectives Teaching guidelines Methodology Time
1 Ultraviolet and Visible Spectroscopy: Introduction – Electronic energy levels, electronic transitions and selection rules. Students should be hands on UV spectrra and should be able to take out desired infromation To cover the each and every spect of ultravoilet spectroscopy, woodward Fieser’s rule for calculating lambda max value 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 8
The origin, general appearance and designation of UV bands, absorption laws and measurement of absorption intensity,
chromophores, auxochromes, bathochromic shift, hypsocromic shift, hypochromic effect, hyperchromic effect .The ultraviolet spectrometer
Wood-ward and Fieser’s rules for calculating ultraviolet absorption maxima for substituted dienes and conjugated dienes, unsaturated carbonyl compounds  and aromatic carbonyl compounds
2 IR Spectroscopy: Introduction – basic theory and instrumentation including FT IR infrared spectrum. Students should be hands on IR spectrra and should be able to take out informtaion as what type of functional group or other information To cover the basic theory as well as detail pricile of IR spectroscopy and its application in the structural elucidation of organic compound 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 8
Absorption of infrared radiation and molecular vibrations.
 Intensity and position of infrared absorption bands,
 bands resulting from combination or difference of vibrational frequencies or by the interaction of overtones (or combination bands) with the fundamental vibrations (fermi resonance).
Frequency of vibrations of a diatomic molecule,
spectral features of major functional groups: alkanes, alkenes,
spectral features of major functional groups:  alkynes, aromatic compounds, alcohols, ethers
3 NMR Spectroscopy: Introduction – spin active nuclei behave as spinning nuclear magnets, orientation of spinning nuclear magnets in a uniform magnetic field and energy description of NMR phenomenon Students should be hands on NMR spectrra and and its working. He/She  should be able to take deduce the sturcture of the compound with proper explaination To cover each small term used and utilised in NMR, its instrumentation, working, what are information, we can get from it, chemical shift , TMS, shielding, deshilding, factors effecting, spin-spin splitting, anisotropic effect, coupling constant, 13C and its comparision with proton nmr 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 18
Continuous wave CW & FT NMR spectrometer
Phenomenon of resonance and relaxation, chemical shift , chemical shift parameters and internal standards
factors affecting the chemical shift: shielding and deshielding of a nucleus, substitution effects leading to empirical  co-relations for proton chemical  shifts
anisotropic effect, effect of changing solvents, effect of hydrogen bonding, influence of chirality on the chemical shifts of enantiomers and intermolecular Vander Walls deshielding,
spin spin coupling, multiplicity of splitting and relative intensity of lines in a multiplet, integration,
mechanism of coupling-one bond coupling  ( 1J), two bond coupling ( 2J) three bond coupling ( 3J) including Karplus relationship.
Techniques for simplification of complex spectra: solvent effects, Lanthanide shift reagents, spin decoupling (double resonance)
 Fourier Transform technique, Nuclear Overhauser effect (NOE).   Effect of sensitivity of C- 13 NMR compared to H–1 NMR, comparison of C–13 NMR and H-1NMR
chemical shifts of C–13 NMR. Simplification of C – 13 spectra by process of decoupling, off resonance decoupling.
4 Mass Spectrometry : Introduction – basic theory , instrumentation, process  of introducing the sample into mass spectrometer. Students should be Understand what mass spectroscopy is and how it is being utilised to indentify a perticular compd. To Cover the principle, theory and application of mass spectroscopy. To explain ORD & CD, its defination, cotton curves and effect, and covering the application of it 1. Lecture,                    2. seminar                    3. Group discussion       4. Assignment               5. Evaluation 6
Methods of generation of positively charged ions, electron ionization method , chemical ionization Techniques
FD and fast atom bombardment (FAB) techniques.  Mass spectrum, base peak, molecular and parent ion, Mass  to  charge ratio (M/Z), relative intensity, fragment ions, even electron rule, nitrogen rule, matastable ions, McLafferty rearrangement and ortho effect.
Determination of molecular weight and molecular formula using mass spectrometry.
ORD & CD : Definition, haloketo rule, octant rule for ketones, Cotton effect and Cotton curves, deduction of absolute configuration.
Admission 2017