Title: Organic Chemistry-I (Code-09040103)
|S.No.||Topic||Domain||Hours as per UGC|
|1||Unit-1 Delocalized chemical bonding –conjugation, cross conjugation, resonance, hyperconjugation , tautomerism,||Must Know||11|
|Aromaticity in benzenoid and non-benzenoid compounds, alternant and non-alternant hydrocarbons, Huckel’s rule,|
|energy level of p-molecular orbitals, annulenes, antiaromaticity, homo-aromaticity, PMO approach,|
|Bonds weaker than covalent, addition compounds, crown ether complexes and cryptands, inclusion compounds, cyclodextrins, catenanes and rotaxanes||Nice to know|
|2||Unit-2 Chirality, elements of symmetry, molecules with more than one chiral centre, diastereomerism.||Must Know||12|
|Determination of relative and absolute configuration (octant rule excluded) with special reference to lactic acid, aniline & mandelic acid.|
|Methods of resolution, optical purity, prochirality, enantiotopic and diastereotopic atoms, groups and faces, asymmetric synthesis, cram’s rule and its modifications, prelog’s rule,|
|conformational analysis of cycloalkanes (upto six membered rings), decalins, conformations of sugars, optical activity in absence of chiral carbon (biphenyls, allenes and spiranes),||Desirable to know|
|chirality due to helical shape, geometrical isomerism in alkenes and oximes, methods of determining the configuration.|
|3||Unit- 3 Types of mechanisms, types of reactions, thermodynamic and kinetic requirements, kinetic and thermodynamic control,||Must Know||9|
|Hammond’s postulate, Curtin-Hammett principle. Potential energy diagrams, transition states and intermediates, methods of determining mechanisms, isotope effects.|
|Hard and soft acids and bases. Generation, structure, stability and reactivity of carbocations, carbanions, free radicals, carbenes and nitrenes.|
|Effect of structure on reactivity. The Hammett equation and linear free energy relationship, substituent and reaction constants. Taft equation.||Desirable to know|
|4||Unit – 4 Type of naturally occurring sugar, Deoxy sugars, amino sugars and branch chain sugars||Desirable to know||8|
|general methods of determination of structure and ring size with particular reference to maltose, lactose, sucrose, starch and cellulose.|
|Various classes of dyes, synthetic dyes including heterocyclic dyes, interaction between dyes and fibers, Structure elucidation of indigo and Alizarin.||Nice to know|
- March, Jerry. Advanced Organic Chemistry Reactions Mechanism and Structure.
- Sykes, Peter. Guide Book to Mechanism in Organic Chemistry.
- Morrison, R.T. and R.N. Boyd. Organic Chemistry.
- Mukherji, S.M. and S.P. Singh. Reaction Mechanism in Organic Chemistry.
- Nasipuri, D. Stereochemistry of Organic Compounds.
- Kalsi, P.S. Stereochemistry of Organic Compounds.
- Bhutani,S.P. Carbohydrates.
- Finar, I.L. Organic Chemistry.
- Allen, R.L.M. Color Chemistry.
- Venkatraman, K. Chemistry of Synthetic Dyes.