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Title: Organic Chemistry I (Code-09040103) | First Sem | Master of Chemistry

Title: Organic Chemistry-I  (Code-09040103)

S.No. Topic Domain Hours as per UGC
1 Unit-1                                                                           Delocalized chemical bonding –conjugation, cross conjugation, resonance, hyperconjugation , tautomerism, Must Know 11
Aromaticity in benzenoid and non-benzenoid compounds, alternant and non-alternant hydrocarbons, Huckel’s rule,
energy level of p-molecular  orbitals, annulenes, antiaromaticity, homo-aromaticity, PMO approach,
Bonds weaker than covalent, addition compounds, crown ether complexes and cryptands, inclusion compounds, cyclodextrins, catenanes and rotaxanes Nice to know
2 Unit-2                                                                              Chirality, elements of symmetry, molecules with more than one chiral centre, diastereomerism. Must Know 12
Determination of relative and absolute configuration (octant rule excluded) with special reference to lactic acid, aniline & mandelic acid.
Methods of resolution, optical purity, prochirality, enantiotopic and diastereotopic atoms, groups and faces, asymmetric synthesis, cram’s rule and its modifications, prelog’s rule,
conformational analysis of cycloalkanes (upto six membered rings), decalins, conformations of sugars, optical activity in absence of chiral carbon (biphenyls, allenes and spiranes), Desirable to know
chirality due to helical shape, geometrical isomerism in alkenes and oximes, methods of determining the configuration.
3 Unit- 3                                                                                    Types of mechanisms, types of reactions, thermodynamic and kinetic requirements, kinetic and thermodynamic control, Must Know 9
Hammond’s postulate, Curtin-Hammett principle.  Potential energy diagrams, transition states and intermediates, methods of determining mechanisms, isotope effects.
Hard and soft acids and bases.  Generation, structure, stability and reactivity of carbocations, carbanions, free radicals, carbenes and nitrenes.
 Effect of structure on reactivity.  The Hammett equation and linear free energy relationship, substituent and reaction constants.  Taft equation. Desirable to know
4  Unit – 4                                                                                   Type of naturally occurring sugar, Deoxy sugars, amino sugars and branch chain sugars Desirable to know 8
 general methods of determination of structure and ring size with particular reference to maltose, lactose, sucrose, starch and cellulose.
Various classes of dyes, synthetic dyes including heterocyclic dyes, interaction between dyes and fibers, Structure elucidation of indigo and Alizarin. Nice to know

Books Recommended:

  1. March, Jerry. Advanced Organic Chemistry Reactions Mechanism and Structure.
  2. Sykes, Peter. Guide Book to Mechanism in Organic Chemistry.
  3. Morrison, R.T. and R.N. Boyd. Organic Chemistry.
  4. Mukherji, S.M. and S.P. Singh. Reaction Mechanism in Organic Chemistry.
  5. Nasipuri, D. Stereochemistry of Organic Compounds.
  6. Kalsi, P.S. Stereochemistry of Organic Compounds.
  7. Bhutani,S.P. Carbohydrates.
  8. Finar, I.L. Organic Chemistry.
  9. Allen, R.L.M. Color Chemistry.
  10. Venkatraman, K. Chemistry of Synthetic Dyes.
Admission 2017