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Title: Organic Special -I (Code-09040313) | Third Sem | Master of Chemistry

 

Title: Organic Special -I  (Code-09040313)

S.No. Topic Domain Hours as per UGC
1 Ultraviolet and Visible Spectroscopy: Introduction – Electronic energy levels, electronic transitions and selection rules. Must Know 8
The origin, general appearance and designation of UV bands, absorption laws and measurement of absorption intensity,
chromophores, auxochromes, bathochromic shift, hypsocromic shift, hypochromic effect, hyperchromic effect .The ultraviolet spectrometer Desirable to know
Wood-ward and Fieser’s rules for calculating ultraviolet absorption maxima for substituted dienes and conjugated dienes, unsaturated carbonyl compounds  and aromatic carbonyl compounds Must Know
2 IR Spectroscopy: Introduction – basic theory and instrumentation including FT IR infrared spectrum. Must Know 8
Absorption of infrared radiation and molecular vibrations.
 Intensity and position of infrared absorption bands,
 bands resulting from combination or difference of vibrational frequencies or by the interaction of overtones (or combination bands) with the fundamental vibrations (fermi resonance). Nice to know
Frequency of vibrations of a diatomic molecule,
spectral features of major functional groups: alkanes, alkenes, Desirable to know
spectral features of major functional groups:  alkynes, aromatic compounds, alcohols, ethers
3 NMR Spectroscopy: Introduction – spin active nuclei behave as spinning nuclear magnets, orientation of spinning nuclear magnets in a uniform magnetic field and energy description of NMR phenomenon Must Know 18
Continuous wave CW & FT NMR spectrometer Nice to know
Phenomenon of resonance and relaxation, chemical shift , chemical shift parameters and internal standards Must Know
factors affecting the chemical shift: shielding and deshielding of a nucleus, substitution effects leading to empirical  co-relations for proton chemical  shifts
anisotropic effect, effect of changing solvents, effect of hydrogen bonding, influence of chirality on the chemical shifts of enantiomers and intermolecular Vander Walls deshielding,
spin spin coupling, multiplicity of splitting and relative intensity of lines in a multiplet, integration,
mechanism of coupling-one bond coupling  ( 1J), two bond coupling ( 2J) three bond coupling ( 3J) including Karplus relationship.
Techniques for simplification of complex spectra: solvent effects, Lanthanide shift reagents, spin decoupling (double resonance) Nice to know
 Fourier Transform technique, Nuclear Overhauser effect (NOE).   Effect of sensitivity of C- 13 NMR compared to H–1 NMR, comparison of C–13 NMR and H-1NMR Must Know
chemical shifts of C–13 NMR. Simplification of C – 13 spectra by process of decoupling, off resonance decoupling. Desirable to know
4 Mass Spectrometry : Introduction – basic theory , instrumentation, process  of introducing the sample into mass spectrometer. Must Know 6
Methods of generation of positively charged ions, electron ionization method , chemical ionization Techniques
FD and fast atom bombardment (FAB) techniques.  Mass spectrum, base peak, molecular and parent ion, Mass  to  charge ratio (M/Z), relative intensity, fragment ions, even electron rule, nitrogen rule, matastable ions, McLafferty rearrangement and ortho effect.
Determination of molecular weight and molecular formula using mass spectrometry. Desirable to know
ORD & CD : Definition, haloketo rule, octant rule for ketones, Cotton effect and Cotton curves, deduction of absolute configuration. Nice to know

 

Books Recommended:

  1. Silverstein, R.M., G.C. Bassler and T.C. Morrill. Spectroscopic Identification of Organic Compounds.
  2. Abraham, R.J., J. Fisher and P. Loftus. Introduction to NMR Spectroscopy.
  3. Dyer, J.R. Application of Spectroscopy of Organic Compounds.
  4. Williams, D.H. and I. Fleming Spectroscopic Methods in Organic Chemistry.
  5. Jag Mohan. Organic Spectroscopy.
  6. Kemp, W. Organic Spectroscopy.
  7. Pavia. Organic Spectroscopy.