Title: Organic Special -I (Code-09040313)
|S.No.||Topic||Domain||Hours as per UGC|
|1||Ultraviolet and Visible Spectroscopy: Introduction – Electronic energy levels, electronic transitions and selection rules.||Must Know||8|
|The origin, general appearance and designation of UV bands, absorption laws and measurement of absorption intensity,|
|chromophores, auxochromes, bathochromic shift, hypsocromic shift, hypochromic effect, hyperchromic effect .The ultraviolet spectrometer||Desirable to know|
|Wood-ward and Fieser’s rules for calculating ultraviolet absorption maxima for substituted dienes and conjugated dienes, unsaturated carbonyl compounds and aromatic carbonyl compounds||Must Know|
|2||IR Spectroscopy: Introduction – basic theory and instrumentation including FT IR infrared spectrum.||Must Know||8|
|Absorption of infrared radiation and molecular vibrations.|
|Intensity and position of infrared absorption bands,|
|bands resulting from combination or difference of vibrational frequencies or by the interaction of overtones (or combination bands) with the fundamental vibrations (fermi resonance).||Nice to know|
|Frequency of vibrations of a diatomic molecule,|
|spectral features of major functional groups: alkanes, alkenes,||Desirable to know|
|spectral features of major functional groups: alkynes, aromatic compounds, alcohols, ethers|
|3||NMR Spectroscopy: Introduction – spin active nuclei behave as spinning nuclear magnets, orientation of spinning nuclear magnets in a uniform magnetic field and energy description of NMR phenomenon||Must Know||18|
|Continuous wave CW & FT NMR spectrometer||Nice to know|
|Phenomenon of resonance and relaxation, chemical shift , chemical shift parameters and internal standards||Must Know|
|factors affecting the chemical shift: shielding and deshielding of a nucleus, substitution effects leading to empirical co-relations for proton chemical shifts|
|anisotropic effect, effect of changing solvents, effect of hydrogen bonding, influence of chirality on the chemical shifts of enantiomers and intermolecular Vander Walls deshielding,|
|spin spin coupling, multiplicity of splitting and relative intensity of lines in a multiplet, integration,|
|mechanism of coupling-one bond coupling ( 1J), two bond coupling ( 2J) three bond coupling ( 3J) including Karplus relationship.|
|Techniques for simplification of complex spectra: solvent effects, Lanthanide shift reagents, spin decoupling (double resonance)||Nice to know|
|Fourier Transform technique, Nuclear Overhauser effect (NOE). Effect of sensitivity of C- 13 NMR compared to H–1 NMR, comparison of C–13 NMR and H-1NMR||Must Know|
|chemical shifts of C–13 NMR. Simplification of C – 13 spectra by process of decoupling, off resonance decoupling.||Desirable to know|
|4||Mass Spectrometry : Introduction – basic theory , instrumentation, process of introducing the sample into mass spectrometer.||Must Know||6|
|Methods of generation of positively charged ions, electron ionization method , chemical ionization Techniques|
|FD and fast atom bombardment (FAB) techniques. Mass spectrum, base peak, molecular and parent ion, Mass to charge ratio (M/Z), relative intensity, fragment ions, even electron rule, nitrogen rule, matastable ions, McLafferty rearrangement and ortho effect.|
|Determination of molecular weight and molecular formula using mass spectrometry.||Desirable to know|
|ORD & CD : Definition, haloketo rule, octant rule for ketones, Cotton effect and Cotton curves, deduction of absolute configuration.||Nice to know|
- Silverstein, R.M., G.C. Bassler and T.C. Morrill. Spectroscopic Identification of Organic Compounds.
- Abraham, R.J., J. Fisher and P. Loftus. Introduction to NMR Spectroscopy.
- Dyer, J.R. Application of Spectroscopy of Organic Compounds.
- Williams, D.H. and I. Fleming Spectroscopic Methods in Organic Chemistry.
- Jag Mohan. Organic Spectroscopy.
- Kemp, W. Organic Spectroscopy.
- Pavia. Organic Spectroscopy.